
$104 Cheap American Airlines flights from Knoxville to Portland (TYS to PWM)
Find The Best Day To Fly from Knoxville to Portland
Amazing American Airlines TYS to PWM Flight Deals
The cheapest flights to Portland Intl. Jetport found within the past 7 days were $366 round trip and $104 one way. Prices and availability subject to change. Additional terms may apply.
PWM From TYS Economy Coach Packages on Similar Airlines



Frequently asked questions
Discover our best American Airlines flight from Knoxville TYS to Portland PWM
To find the best deals on flights to Knoxville from Portland with American Airlines, just enter your travel dates, filter by American Airlines, and hit search. You’ll find flights to choose from and can sort by price, flight duration, and arrival or departure time.
Return flights from Knoxville TYS to Portland PWM with American Airlines
If you’re planning a round trip, booking return flights with American Airlines is usually the most cost-effective option. With airfares ranging from $366 to $560, it’s easy to find a flight that suits your budget. Prices and availability subject to change. Additional terms may apply.
Book one-way American Airlines flights from Knoxville TYS to Portland PWM
A one-way ticket gives you much greater flexibility—allowing you to choose your return date, destination, and time whenever you’re ready. By booking in advance you can find great deals on one-way tickets too. Right now, a one-way American Airlines flight from Knoxville to Portland costs from $104. Prices and availability subject to change. Additional terms may apply.
The easy way to find cheap flights to Portland PWM from Knoxville TYS with American Airlines
To find a cheap American Airlines flight from Knoxville TYS to Portland PWM, sort your search results by price or filter by budget. Thanks to Travelocity’s Price Match Promise, if you find a better airfare deal anywhere else within 24 hours, we’ll credit or refund the difference.
How to find our best airfare deals on American Airlines flights from Knoxville TYS to Portland PWM
If you’re looking for cheap flights, it helps to be flexible when it comes to your travel dates. You’ll usually find lower cost tickets when you travel during quieter months such as September, or if you book a flight with a stopover.
Find nonstop flights from Knoxville TYS to Portland PWM with American Airlines
If you’re keen to be on Portland soil fast, don’t waste time with a stopover—filter your search results to show direct American Airlines flights only. The journey takes around hour(s) min(s) – so you’ll be there before you know it.
Flexible airline tickets for American Airlines flights from Knoxville TYS to Portland PWM
Make sure you’re not out of pocket if plans change by choosing a flexible ticket with penalty-free amendment and cancellation options. Use our ‘no change fee’ filter to see which flights have this option.
There are a lot of reasons to book your flights to Portland PWM from Knoxville TYS with American Airlines on Travelocity
At Travelocity our vast and up-to-the-minute inventory puts all of our best flight deals in one place. So, whether you’re traveling on business or jetting off with friends and family, you can trust Travelocity to get you there.
Airport code | Country | Airport name | Number of flights |
---|---|---|---|
DFW | USA | Dallas-Fort Worth Intl. | 599 |
CLT | USA | Charlotte-Douglas Intl. | 536 |
ORD | USA | O'Hare Intl. | 317 |
PHL | USA | Philadelphia Intl. | 247 |
MIA | USA | Miami Intl. | 193 |
DCA | USA | Ronald Reagan Washington National | 152 |
PHX | USA | Sky Harbor Intl. | 141 |
LAX | USA | Los Angeles Intl. | 81 |
LGA | USA | LaGuardia | 72 |
BOS | USA | Logan Intl. | 57 |
Travelers ❤️ these 🏨 after their flight to Portland

Clarion Hotel Portland
Reviewed on Sep 14, 2025

Embassy Suites by Hilton Portland Maine
Reviewed on Sep 15, 2025

La Quinta Inn & Suites by Wyndham Portland DT/Maine Med
Reviewed on Sep 16, 2025
Popular American Airlines Flight Routes from TYS
Top Flights for American Airlines originating from TYS
Domestic
- New York to San Juan (JFK - SJU)
- Boston to Orlando (BOS - MCO)
- New York to Santiago (JFK - STI)
- Newark Liberty Intl. Airport to Orlando (EWR - MCO)
- Newark Liberty Intl. Airport to Orlando (EWR - MCO)
- Philadelphia to Orlando (PHL - MCO)
- Los Angeles to Paris (LAX - CDG)
- Newark Liberty Intl. Airport to San Juan (EWR - SJU)
- Philadelphia to Orlando (PHL - MCO)
- Newark Liberty Intl. Airport to Santiago (EWR - STI)
International
- Los Angeles to Paris (LAX - CDG)
- Los Angeles to San Salvador (LAX - SAL)
- New York to Santo Domingo (JFK - SDQ)
- Chicago to Mexico City (ORD - MEX)
- New York to San Juan (JFK - SJU)
- New York to Santo Domingo (JFK - SDQ)
- New York to Montego Bay (JFK - MBJ)
- New York to Montego Bay (JFK - MBJ)
- Los Angeles to Paris (LAX - CDG)
- Chicago to Mexico City (ORD - MEX)
Most Popular
- DFW to BNA Flights
- MSP to BNA Flights
- ATL to BNA Flights
- LAX to BNA Flights
- BNA to JFK Flights
- DTW to BNA Flights
- JetBlue Airways Boston (BOS) to Nashville (BNA) flights
- PHL to BNA Flights
- BNA to ATL Flights
- BNA to DFW Flights
- TPA to BNA Flights
- Delta Memphis (MEM) to Las Vegas (LAS) flights
- BNA to LAX Flights
- BNA to TPA Flights
- RDU to BNA Flights
- MEM to ATL Flights
- JetBlue Airways New York (JFK) to Nashville (BNA) flights
- JFK to BNA Flights
- BNA to MCO Flights
- ORD to BNA Flights
- BNA to DEN Flights
- MEM to MCO Flights
- CLT to BNA Flights
- BNA to MIA Flights
- MEM to DFW Flights
- American Airlines Nashville (BNA) to Las Vegas (LAS) flights
- BNA to ORD Flights
- SLC to BNA Flights
- PHX to BNA Flights
- MCO to BNA Flights