$239 Cheap American Airlines flights from Des Moines to Knoxville (DSM to TYS)

Discover our best American Airlines flight from Des Moines DSM to Knoxville TYS 

To find the best deals on flights to Des Moines from Knoxville with American Airlines, just enter your travel dates, filter by American Airlines, and hit search. You’ll find flights to choose from and can sort by price, flight duration, and arrival or departure time.  

Return flights from Des Moines DSM to Knoxville TYS with American Airlines 

If you’re planning a round trip, booking return flights with American Airlines is usually the most cost-effective option. With airfares ranging from $249 to $307, it’s easy to find a flight that suits your budget. Prices and availability subject to change. Additional terms may apply. 

Book one-way American Airlines flights from Des Moines DSM to Knoxville TYS 

A one-way ticket gives you much greater flexibility—allowing you to choose your return date, destination, and time whenever you’re ready. By booking in advance you can find great deals on one-way tickets too. Right now, a one-way American Airlines flight from Des Moines to Knoxville costs from $239. Prices and availability subject to change. Additional terms may apply. 

The easy way to find cheap flights to Knoxville TYS from  Des Moines DSM with American Airlines 

To find a cheap American Airlines flight from Des Moines DSM to Knoxville TYS, sort your search results by price or filter by budget. Thanks to Travelocity’s Price Match Promise, if you find a better airfare deal anywhere else within 24 hours, we’ll credit or refund the difference. 

How to find our best airfare deals on American Airlines flights from Des Moines DSM to Knoxville TYS 

If you’re looking for cheap flights, it helps to be flexible when it comes to your travel dates. You’ll usually find lower cost tickets when you travel during quieter months such as September, or if you book a flight with a stopover. 

Find nonstop flights from Des Moines DSM to Knoxville TYS with American Airlines 

If you’re keen to be on Knoxville soil fast, don’t waste time with a stopover—filter your search results to show direct American Airlines flights only. The journey takes around hour(s) min(s) – so you’ll be there before you know it. 

Flexible airline tickets for American Airlines flights from Des Moines DSM to Knoxville TYS 

Make sure you’re not out of pocket if plans change by choosing a flexible ticket with penalty-free amendment and cancellation options. Use our ‘no change fee’ filter to see which flights have this option.  

There are a lot of reasons to book your flights to Knoxville TYS from  Des Moines DSM with American Airlines on Travelocity 

At Travelocity our vast and up-to-the-minute inventory puts all of our best flight deals in one place. So, whether you’re traveling on business or jetting off with friends and family, you can trust Travelocity to get you there.