Search Panama City luxury spa hotels
Our top choices for a great stay
Sofitel Legend Casco Viejo, Panama City
$347 nightly
The price is $381 total per night from Sep 20 to Sep 21
$381 total
Sep 20 - Sep 21
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property ...
9.8/10 Exceptional! (734 reviews)
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
$269 nightly
The price is $296 total per night from Sep 7 to Sep 8
$296 total
Sep 7 - Sep 8
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (742 reviews)
Bristol Panama, a Registry Collection Hotel
$249 nightly
The price is $274 total per night from Sep 6 to Sep 7
$274 total
Sep 6 - Sep 7
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,001 reviews)
Hilton Panama
$241 nightly
The price is $265 total per night from Sep 20 to Sep 21
$265 total
Sep 20 - Sep 21
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the helpful staff in our ...
9/10 Wonderful! (1,000 reviews)
Megapolis Hotel Panamá
$163 nightly
The price is $179 total per night from Sep 3 to Sep 4
$179 total
Sep 3 - Sep 4
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.4/10 Very Good! (1,687 reviews)
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
$155 nightly
The price is $171 total per night from Aug 31 to Sep 1
$171 total
Aug 31 - Sep 1
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and a casino. Our guests praise the helpful staff and the clean rooms in ...
Waldorf Astoria Panama
$266 nightly
The price is $292 total per night from Sep 27 to Sep 28
$292 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
Hotel La Compañía Casco Antiguo
$327 nightly
The price is $360 total per night from Sep 19 to Sep 20
$360 total
Sep 19 - Sep 20
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 5 restaurants. Our guests praise the helpful staff and the property ...
Hyatt Regency Panama City
$225 nightly
The price is $248 total per night from Sep 10 to Sep 11
$248 total
Sep 10 - Sep 11
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and 2 restaurants. Popular attractions Albrook Shopping Mall and Avenida ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
