See all properties

Hilton Jacksonville At Mayo Clinic

4.5 star property
4.5-star luxury hotel near Mayo Clinic Florida

Choose dates to view prices

Photo gallery for Hilton Jacksonville At Mayo Clinic

Breakfast, lunch, dinner served; American cuisine
Exterior
Lobby
Meeting facility
Premium bedding, in-room safe, blackout drapes, iron/ironing board

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Breakfast available
  • Bar
  • 24/7 front desk
  • Room service
  • Housekeeping
  • Pool

Explore the area

View in a map
4745 Transformation Way, Jacksonville, FL, 32224
  • Place, Mayo Clinic Florida
    ‪1 min walk‬
  • Place, St. Johns Town Center
    ‪7 min drive‬
  • Place, Mayport Naval Station
    ‪17 min drive‬
  • Airport, Jacksonville, FL (JAX-Jacksonville Intl.)
    ‪33 min drive‬

Room options

View all photos for Room, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed

  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Deluxe Room, 1 King Bed (Water View)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Corner

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Corner

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Zero Count)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Zero Count)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View, Roll-In Shower)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 2 Queen Beds

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds

  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Water View, Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Water View, Hearing)

  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub

  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Hearing)

  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds (Water View)

  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub (View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub (View)

  • Sleeps 4
  • 2 Queen Beds

You may also like

Ad
View from property

DoubleTree by Hilton Hotel Jacksonville Riverfront

Downtown Jacksonville
  • Pool
  • Pet friendly
  • Free WiFi
  • Restaurant
3.4 out of 5, 1,430 reviews
$106 nightly
The price is $120
Nov 29 - Nov 30
Total with taxes and fees
DoubleTree by Hilton Hotel Jacksonville Riverfront

About the neighborhood

Jacksonville

In Jacksonville .At this Jacksonville hotel, you'll be within half a mile (1 km) of Mayo Clinic Florida and 6 miles (10 km) of Windsor Commons Shopping Center. Windsor Parke Golf Club and Adventure Landing are also within 6 miles (10 km).

What's nearby

  • Mayo Clinic Florida - 1 min walk - 0.0 miles
  • University of North Florida - 5 min drive - 5.2 miles
  • St. Johns Town Center - 7 min drive - 6.8 miles
  • Mayport Naval Station - 17 min drive - 12.0 miles
  • Jacksonville Naval Air Station - 29 min drive - 29.2 miles

Getting around

  • Jacksonville Station - 28 min drive
  • Jacksonville International Airport (JAX) - 31 min drive

Restaurants

  • ‪Culver's #964 - ‬3 min drive
  • ‪M Brothers at Mayo - ‬14 min walk
  • ‪Starbucks - ‬3 min drive
  • ‪Circle K - ‬16 min walk
  • ‪Mayo Clinic - Employee Cafeteria - ‬14 min walk

About this property

Hilton Jacksonville At Mayo Clinic

4.5-star luxury hotel near Mayo Clinic Florida
Hilton Jacksonville At Mayo Clinic offers its guests an outdoor pool and a fitness center. There's a restaurant on site. You can enjoy a drink at the bar/lounge. Public spaces have free WiFi.

Business amenities include 12 meeting rooms and coworking spaces. Event space at this hotel measures 20000 square feet (1858 square meters) and includes conference space. The luxury Hilton Jacksonville At Mayo Clinic also features concierge services, laundry facilities, and dry cleaning/laundry services. A free area shuttle within 350 yards is available. Self parking is free.

This 4.5-star Jacksonville hotel is smoke free.

  • 1 building
  • 252 guestrooms or units
  • 8 levels
  • Meeting rooms
  • 20000 sq ft of conference space
  • 1858 sq m of conference space
  • Built in 2025
  • Poolside lounge chairs
  • Umbrellas for the pool
  • Charging station for electric cars
  • Conference space
  • Breakfast available (surcharge)
  • Dry cleaning
  • Self-service laundry
  • Front desk (24 hours)
  • Express check-out
  • Storage area for luggage
  • Concierge
  • Wedding services available
  • Convenience store
  • Television in lobby
  • Bellhop
  • No smoking on site
  • Bar or lounge
  • Dining venue
Hilton Jacksonville At Mayo Clinic offers 252 air-conditioned accommodations with laptop-compatible safes and complimentary bottled water. Beds feature premium bedding. 55-inch Smart televisions come with premium cable channels and Netflix. Bathrooms include bathtubs or showers and hair dryers.

Guests can surf the web using the complimentary wireless Internet access (speed: 25+ Mbps). Business-friendly amenities include phones; local and long-distance calls are complimentary (restrictions may apply). Additionally, rooms include coffee/tea makers and irons/ironing boards. Housekeeping is provided daily.

Similar properties

On the beach, white sand, surfing, kayaking
Margaritaville Jacksonville Beach
  • Pool
  • Free WiFi
  • Restaurant
  • Air conditioning
4.5 out of 5, Wonderful, 3,356 reviews
$138 nightly
The price is $157
Nov 18 - Nov 19
Total with taxes and fees
Margaritaville Jacksonville Beach

Property amenities

Family friendly

  • Free area shuttle
  • Grocery/convenience store
  • In-room crib
  • Laundry facilities
  • Mini-fridge
  • Outdoor pool
  • Rollaway/extra bed (surcharge)

Internet

  • Available in all rooms: Free WiFi
  • In-room WiFi speed: 25+ Mbps
  • Available in some public areas: Free WiFi

Parking and transportation

  • Electric car charging station on site
  • Free area shuttle up to 350 yds
  • Free uncovered self parking on site

Food and drink

  • Daily buffet breakfast available 6:00 AM to 10:30 AM for a fee: USD 26.99 to 26.99 for adults and USD 15 to 21 for children
  • A bar/lounge
  • A restaurant

Things to do

  • Gym
  • Outdoor pool
  • TV in common areas

Accessibility

  • Tile flooring in public areas

Room amenities

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Bedroom

  • Blackout drapes
  • Free crib
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathtub or shower
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Food and drink

  • Coffee/tea maker
  • Free bottled water
  • Late-night room service
  • Mini-fridge

More

  • Air conditioning
  • Free local calls
  • Free long-distance calls
  • Heating
  • Iron/ironing board
  • Laptop-compatible safe
  • LED lighting
  • Mobile key entry
  • Phone
  • Recycling
  • Water-efficient showers
  • Water-efficient toilets

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 5:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM
Contactless check-out available
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
The credit card used to book the reservation must be presented by the cardholder at check-in along with matching photo identification, and other arrangements must be coordinated with the property prior to arrival

Access methods

Staffed front desk

Pets

  • No pets allowed

Children and extra beds

  • Children are welcome.
  • Kids stay free! Up to 2 children 18 years old and younger stay free, per registered adult, when using existing bedding.
  • Rollaway/extra beds are available for USD 50.00 per night.
  • Free cribs (infant beds)!

Property payment types

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Breakage deposit: USD 100 per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for buffet breakfast: approximately USD 26.99 to 26.99 for adults, and USD 15 to 21 for children
  • Rollaway bed fee: USD 50.00 per night

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards and debit cards; cash is not accepted
This property reserves the right to pre-authorize the guest's credit card prior to arrival.
Cashless transactions are available
Safety features at this property include a carbon monoxide detector and a smoke detector
Charges for extra guests may apply and vary according to property policy.
A credit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation. This property accepts Visa, Mastercard, American Express, Discover, Diners Club, Carte Blanche, and debit cards. Cash is not accepted. This property reserves the right to pre-authorize the guest's credit card prior to arrival.
    For guests' safety, the property includes a carbon monoxide detector and a smoke detector in each accommodation. Cashless payment methods are available for all transactions and guests can access their rooms with a mobile device.

We should mention

  • Pool access available from 8:00 AM to 10:00 PM.
  • Up to 2 children 18 years old and younger stay free, per registered adult, in the same room as the parent or guardian when using existing bedding.
  • Registered guests are the only ones allowed to be in guestrooms.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Hilton Jacksonville At Mayo Clinic Hotel
Hilton Jacksonville At Mayo Clinic Jacksonville
Hilton Jacksonville At Mayo Clinic Hotel Jacksonville

Frequently asked questions

How close is Hilton Jacksonville At Mayo Clinic to the airport?

Hilton Jacksonville At Mayo Clinic is 10.8 mi (14-min drive) away from the Jacksonville, FL (CRG-Jacksonville Executive at Craig) airport, the closest popular airport to the property.

How much does it cost to stay at Hilton Jacksonville At Mayo Clinic?

As of Nov 17, 2025, prices found for a 1-night stay for 2 adults at Hilton Jacksonville At Mayo Clinic on Nov 27, 2025 start from $122.18, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Does Hilton Jacksonville At Mayo Clinic have an airport shuttle?

Airport shuttle services are not available at Hilton Jacksonville At Mayo Clinic.

How close is Hilton Jacksonville At Mayo Clinic to the beach?

This hotel is 5.4 mi (10-min drive) from Northeast Florida Beaches and 7.8 mi (14-min drive) from Atlantic Beach. Don't forget your sunscreen!

Does Hilton Jacksonville At Mayo Clinic offer free breakfast?

Free breakfast isn’t offered at Hilton Jacksonville At Mayo Clinic, but buffet breakfast is offered for a fee of between USD 26.99 and 26.99 for adults, USD 15 and 21 for children. It's available every day from 6:00 AM to 10:30 AM.

Is there a casino at Hilton Jacksonville At Mayo Clinic?

No, there is no casino at this hotel.

What time is check-in at Hilton Jacksonville At Mayo Clinic?

Check-in start time: 4:00 PM; Check-in end time: 5:00 AM.

Is there free parking at Hilton Jacksonville At Mayo Clinic?

This hotel offers free self parking.

Does Hilton Jacksonville At Mayo Clinic have a pool?

Hilton Jacksonville At Mayo Clinic features an outdoor pool. Guests can enjoy pool access from 8:00 AM to 10:00 PM.

Does Hilton Jacksonville At Mayo Clinic have a restaurant?

Hilton Jacksonville At Mayo Clinic is home to Coastal Kitchen, which features American cuisine.

Does Hilton Jacksonville At Mayo Clinic have a spa?

There are no spa services available at this hotel.

How close is Hilton Jacksonville At Mayo Clinic to downtown Jacksonville?

Hilton Jacksonville At Mayo Clinic is 13.7 mi away from Jacksonville.