The property is a historic hotel which adds to its charm but also makes it feel a bit dated.
One of the big perks is that the hotel itself is not massive. No matter what room you are in, you are not going to have a long hike to get to your room as there are not that many rooms were floor.
That being said, the property is not really set up for tons of people. There are two elevators, both pretty small, and they are not the quickest.
The room itself was spacious and clean. We needed an extra bed and the staff accommodated us with a rollaway.
The main reason we chose the Mayflower was its proximity to Seattle's awesome railway system. One of the main hubs, Westlake, is literally across the street from the hotel. However, be advised. I used Google Maps to navigate us to the hotel from the station and it told us to take exit B out of Westlake Station. However, that exit is tied to the Westlake shopping center and the doors are locked when the shopping center is closed. We found that even when the doors were unlocked you could not really exit. Take the C exits instead.
While the downtown location is convenient, it does also mean more noise (even at night) and interaction with unhoused people, some of whom clearly have mental health issues. It does take a bit of caution to navigate and you are likely to see more butt cracks than you bargained for. But on the flip side, there are countless coffeehouses nearby.