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21c Museum Hotel Louisville

4.5 star property
4.5-star luxury hotel near KFC Yum Center

Choose dates to view prices

Photo gallery for 21c Museum Hotel Louisville

Front of property
Interior
Bar (on property)
Fountain
Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe

Reviews

9.2 out of 10
Wonderful

Popular amenities

  • Spa
  • Room service
  • Pet friendly

Explore the area

View in a map
700 W Main Street, Louisville, KY, 40202
  • Place, Louisville Slugger Museum
    ‪3 min walk‬
  • Place, Kentucky International Convention Center
    ‪8 min walk‬
  • Place, KFC Yum Center
    ‪8 min walk‬
  • Airport, Louisville, KY (SDF-Louisville Intl.)
    ‪11 min drive‬

Room options

View all photos for Deluxe Double Room, 2 Double Beds

Deluxe Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Deluxe Double Room, 2 Double Beds

9.6 out of 10
Exceptional
(30 reviews)
  • 335 sq ft
  • Sleeps 4
  • 2 Double Beds

View all photos for Luxury Double Room, 2 Double Beds

Luxury Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Luxury Double Room, 2 Double Beds

9.0 out of 10
Wonderful
(2 reviews)
  • 435 sq ft
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed

9.6 out of 10
Exceptional
(65 reviews)
  • 350 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Luxury Room, 1 King Bed

Luxury Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Luxury Room, 1 King Bed

9.0 out of 10
Wonderful
(32 reviews)
  • 455 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Suite, Corner

Suite, Corner | Premium bedding, down comforters, minibar, in-room safe

Suite, Corner

  • 660 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Room (Asleep in the Cyclone)

Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe

Room (Asleep in the Cyclone)

  • 500 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Suite (Atrium)

Suite (Atrium) | Premium bedding, down comforters, minibar, in-room safe

Suite (Atrium)

  • 580 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Room, Balcony

Room, Balcony | Premium bedding, down comforters, minibar, in-room safe

Room, Balcony

10.0 out of 10
Exceptional
(1 review)
  • 315 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Double Room, Accessible

Designer toiletries, hair dryer, bathrobes, towels

Deluxe Double Room, Accessible

9.0 out of 10
Wonderful
(2 reviews)
  • 455 sq ft
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

  • 434 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

  • 435 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Apartment, 1 Double Bed (Rooftop)

Apartment, 1 Double Bed (Rooftop) | Premium bedding, down comforters, minibar, in-room safe

Apartment, 1 Double Bed (Rooftop)

  • Sleeps 4
  • 1 Double Bed

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About the neighborhood

Louisville

Downtown Louisville stay.A stay at this Downtown Louisville hotel places you steps from Louisville Slugger Museum and within a 10-minute walk of KFC Yum Center. Ohio River Valley and 21c Museum Hotel are also within half a mile (1 km).

What's nearby

  • Muhammad Ali Center - 3 min walk - 0.2 miles
  • Louisville Slugger Museum - 3 min walk - 0.2 miles
  • Fourth Street Live! - 8 min walk - 0.4 miles
  • Kentucky International Convention Center - 8 min walk - 0.5 miles
  • KFC Yum Center - 8 min walk - 0.5 miles

Getting around

  • Louisville Intl. Airport (SDF) - 10 min drive

Restaurants

  • ‪Heine Brothers' Coffee - ‬3 min walk
  • ‪Vincenzo's Italian Restaurant - ‬5 min walk
  • ‪Mussel & Burger Bar - ‬1 min walk
  • ‪Sunergos Coffee and Espresso Bar - ‬6 min walk
  • ‪Bristol Bar and Grille - ‬2 min walk

About this property

21c Museum Hotel Louisville

4.5-star luxury hotel near KFC Yum Center
21c Museum Hotel Louisville offers its guests a full-service spa and a 24-hour fitness center. There's a restaurant on site. You can enjoy a drink at the bar/lounge. A computer station is on site, and both WiFi and wired Internet are free in public spaces.

A 24-hour business center, meeting rooms, and limo/town car service are available. Event space at this hotel measures 5000 square feet (465 square meters) and includes conference space. Spa services, multilingual staff, and gift shops/newsstands are also featured at the luxury 21c Museum Hotel Louisville. Parking is available for a fee.

This 4.5-star Louisville hotel is smoke free.

  • 1 building
  • 91 guestrooms or units
  • 4 levels
  • Meeting rooms
  • 5000 sq ft of conference space
  • 465 sq m of conference space
  • Built in 2006
  • Charging station for electric cars
  • Business center (24 hours)
  • Conference space
  • Breakfast available (surcharge)
  • Coffee in lobby
  • Dry cleaning
  • Self-service laundry
  • Front desk (24 hours)
  • Staff is multilingual
  • Storage area for luggage
  • Front-desk safe
  • Car service
  • Tour and ticket information
  • Concierge
  • Gift shop
  • Newspapers in lobby (free)
  • ATM
  • Bellhop
  • Elevator
  • No smoking on site
  • Bar or lounge
  • Dining venue
21c Museum Hotel Louisville offers 91 accommodations with iPod docking stations and minibars. Beds feature down comforters and premium bedding. 50-inch LCD televisions come with premium cable channels. Bathrooms include bathrobes, designer toiletries, complimentary toiletries, and hair dryers.

This Louisville hotel provides complimentary wired and wireless Internet access. Business-friendly amenities include desks and laptop-compatible safes; free local calls are provided (restrictions may apply). Additionally, rooms include espresso makers and complimentary bottled water. In-room massages, hypo-allergenic bedding, and change of towels can be requested. A nightly turndown service is provided and housekeeping is offered daily.

Guests can pamper themselves with a trip to the onsite spa, which has 2 treatment rooms. Services include massages.

Awards and affiliations

Eco-Certified Property
This property participates in Green Key Global, a program that measures the property's impact on one or more of the following: environment, community, cultural-heritage, the local economy.

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Property amenities

Family friendly

  • In-room crib
  • Laundry facilities
  • Rollaway/extra bed (surcharge)
  • Soundproofed rooms

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Electric car charging station on site
  • Limo/town car service
  • Valet parking on site (USD 32 per night; includes in/out privileges)
  • Wheelchair-accessible parking available

Food and drink

  • Daily full breakfast available for a fee: USD 5 to 25 per person
  • A bar/lounge
  • A restaurant
  • Coffee and tea in common areas

Things to do

  • 24-hour gym
  • Full-service spa
  • Yoga classes

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Elevator
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible registration desk

Room amenities

Entertainment

  • 50-inch LCD TV with premium cable channels
  • iPod dock

Bedroom

  • Blackout drapes
  • Down comforter
  • Free crib
  • Hypo-allergenic bedding
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathrobes
  • Designer toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service
  • Minibar

More

  • Air conditioning (climate-controlled)
  • Cleaning products are eco-friendly
  • Connecting rooms available
  • Desk
  • Eco-friendly toiletries
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Soundproofed rooms
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4 PM; Check-in end time: midnight
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

  • Pets: USD 40.00 per accommodation, per stay
  • Weight limit: 50 lbs per pet
  • Food and water bowls are available
  • Service animals are exempt from fees

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are available for USD 30.0 per night.
  • Free cribs (infant beds)!

Property payment types

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Service fee: USD 5.00 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for full breakfast: approximately USD 5 to 25 per person
  • Valet parking fee: USD 32 per night (in/out privileges)
  • Pet fee: USD 40.00 per accommodation, per stay
  • Service animals are exempt from fees
  • Rollaway bed fee: USD 30.0 per night

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards; cash is not accepted
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards
This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels)
Charges for extra guests may apply and vary according to property policy.
A credit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation. This property accepts Visa, Mastercard, American Express, and Discover. Cash is not accepted. 
    For guests' safety, the property includes a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards in each accommodation. This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels).

We should mention

  • Reservations are needed for massage services. For reservations, contact the hotel before arrival using the contact information on the booking confirmation.
  • Connecting/adjoining rooms are subject to availability and can be requested by contacting the property at the number on your booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21c Hotel Louisville
21c Hotel Museum
21c Louisville Hotel
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Louisville 21c Hotel
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Museum Hotel 21c
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Frequently asked questions

How close is 21c Museum Hotel Louisville to the airport?

21c Museum Hotel Louisville is 7.1 mi (10-min drive) away from the Louisville Intl. Airport (SDF) airport, the closest popular airport to the property.

How much does it cost to stay at 21c Museum Hotel Louisville?

As of Nov 13, 2025, prices found for a 1-night stay for 2 adults at 21c Museum Hotel Louisville on Nov 24, 2025 start from $179.0, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Does 21c Museum Hotel Louisville have an airport shuttle?

Airport shuttle services are not available at 21c Museum Hotel Louisville.

Does 21c Museum Hotel Louisville offer free breakfast?

Free breakfast isn’t provided at 21c Museum Hotel Louisville, but full breakfast is offered for a fee of between USD 5 and 25 per person.

Is there a casino at 21c Museum Hotel Louisville?

No, there is no casino at this hotel, but Horseshoe Southern Indiana Casino (22-min drive) is nearby.

What time is check-in at 21c Museum Hotel Louisville?

Check-in start time: 4 PM; Check-in end time: midnight.

Is there free parking at 21c Museum Hotel Louisville?

Free parking is not available at this hotel. Valet parking is available for USD 32 per night.

Does 21c Museum Hotel Louisville have a pool?

21c Museum Hotel Louisville does not have a pool.

Does 21c Museum Hotel Louisville have a restaurant?

21c Museum Hotel Louisville is home to Proof on Main, which features light fare and brunch.

Does 21c Museum Hotel Louisville have a spa?

This hotel has a spa, which features massages.

How close is 21c Museum Hotel Louisville to downtown Louisville?

21c Museum Hotel Louisville is 0.4 mi away from Louisville.

21c Museum Hotel Louisville Reviews

Reviews

9.2

Wonderful

Rating 10 - Excellent. 760 out of 1001 reviews
Rating 8 - Good. 138 out of 1001 reviews
Rating 6 - Okay. 60 out of 1001 reviews
Rating 4 - Poor. 23 out of 1001 reviews
Rating 2 - Terrible. 20 out of 1001 reviews

9.6/10

Cleanliness

9.4/10

Staff & service

9.0/10

Amenities

9.6/10

Property conditions & facilities

9.2/10

Eco-friendliness

Reviews

10/10 Excellent

Dwaine

Stayed 4 nights in Aug 2025

10/10 Excellent

Daniel

Stayed 1 night in Aug 2025

10/10 Excellent

Cynthia, Lakewood

Traveled with partner
Liked: Cleanliness, amenities
Favorite in Louisville - such a fun & unique hotel
Stayed 1 night in Aug 2025

10/10 Excellent

Ben

Liked: Cleanliness, staff & service, property conditions & facilities
Errthang
Stayed 1 night in Aug 2025

8/10 Good

Alison

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 6 nights in Jul 2025

10/10 Excellent

Brian

Liked: Cleanliness, staff & service, property conditions & facilities
Nice
Stayed 1 night in Jul 2025

10/10 Excellent

Charles

Stayed 4 nights in Aug 2025

10/10 Excellent

Edward

Stayed 4 nights in Jul 2025

10/10 Excellent

Kathryn, Columbia

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The art gallery was fun. Parking was rough but I chose to do valet and that took care of it. It was pricey but worth it to not have to battle finding parking in the area. The hotel was beautiful and so fun and unique. Close to everything!
Stayed 1 night in Jul 2025

10/10 Excellent

Daniel M

Business traveler
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Centrally located in downtown. Steps to the Ali Center and Louisville Slugger Museum. Staff was friendly and accommodating.
Stayed 3 nights in Jul 2025

6/10 Okay

Nathan

Stayed 1 night in Jul 2025

10/10 Excellent

judith

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Unexpected

Offbeat elegance with just a touch whimsy we throughly enjoyed the 21C. Room was spacious and comfortable and oh so quiet. We loved roaming the galleries and were entertained by the random Penguins. The restaurant was excellent and the staff in the bar and restaurant were stellar. The location was excellent as well.
Stayed 3 nights in Jul 2025

8/10 Good

Verified traveler

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Fun hotel to stay at. I wanted a relaxing stay and that's what I got. TV in room kept freezing up so I ended up watching things from my laptop, but otherwise room was perfect for my needs.
Stayed 2 nights in Jul 2025

10/10 Excellent

Sybil

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The staff was great, ver helpful with answering questions about the city. Restaurant had good food and atmosphere. Loved being surrounded by so many wonderful works of art. We would definitely stay again... it's such a vibe.
Stayed 3 nights in Jun 2025

10/10 Excellent

Halyna

Stayed 2 nights in Jul 2025

10/10 Excellent

Mark

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Jul 2025

6/10 Okay

Glenda

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 4 nights in Jun 2025

10/10 Excellent

Tom

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great Location. Great hotel. Great team members.
Stayed 2 nights in Jul 2025

2/10 Terrible

derek

Stayed 1 night in Jul 2025

8/10 Good

Verified traveler

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
It isn't for families
Stayed 1 night in Jul 2025

10/10 Excellent

George

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 3 nights in Jul 2025

10/10 Excellent

Patricia

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
From the time we walked in to this property the staff was amazing! Anya checked us in and was very friendly and gave us some great food recommendations. This property is quiet and clean. The museum/art aspect is a wonderful piece to the hotel. This property is within 2 blocks of the Louisville Slugger and Mohammed Ali Center...super continent! We would absolutely stay here again!
Stayed 2 nights in Jul 2025

10/10 Excellent

Matt

Stayed 1 night in Jul 2025

10/10 Excellent

Monte

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

21c is Amazing

The hotel and the hotel staff were both excellent. We appreciated the friendliness of every staff member we encountered and the aesthetics of the entire hotel. Our room was very clean, comfortable, appealing and so quiet. We were very pleased with our stay.
Stayed 1 night in Jul 2025

10/10 Excellent

Michael, Austin

Was great
Stayed 4 nights in Jun 2025